Contrary to current guidance, antenatal factor IX levels increase in female carriers of hemophilia B

20260 citationsJournal Articlehybrid Open Access

Authors

Claire Kelly · National Centre for Pharmacoeconomics

Janet Cleary · St. James's Hospital

Catriona Keenan · St. James's Hospital

Isabelle Delachapelle · St. James's Hospital

Leona Connolly · St. James's Hospital

Mary Byrne · St. James's Hospital

Mairéad O’Donovan

Abstract

Contrary to published guidance, FIX:C levels increase during pregnancy in carriers of HB. This work challenges current approaches and counseling provided to carriers of HB and highlights the importance of evaluating FIX:C levels to guide hemostatic management of delivery.

Topics & Keywords

Hemophilia Treatment and Research Blood Coagulation and Thrombosis Mechanisms Blood properties and coagulation

UN Sustainable Development Goals

Gender equality

Publication Details

Published in: Journal of Thrombosis and Haemostasis

DOI: 10.1016/j.jtha.2026.01.029

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