Atypical hemolytic-uremic syndrome

A clinical case of atypical hemolytic uremic syndrome in an adult man is presented. Atypical hemolytic uremic syndrome (aHUS) is an orphan disease that affects various organs and systems and is accompanied by extremely high mortality. aHUS is based on uncontrolled activation of the alternative complement pathway, leading to generalized thrombus formation in the vessels of the microcirculatory bed. High mortality in aHUS is due to several reasons: extremely rare incidence of the disease and, as a result, low awareness of it by doctors, nonspecific symptoms at the onset of aHUS, rapid development of multiple organ failure with kidney damage due to catastrophic generalized thrombus formation in the microcirculatory bed.