Tissue Iron Predicts Metformin Responsiveness in a Mouse Model and in Humans with Type 2 Diabetes

20260 citationsJournal Articlegold Open Access

Authors

Alexandria Harrison · Wake Forest University

Chinenye Usoh · W. G. (Bill) Hefner VA Medical Center

Sandy Sink · Wake Forest University

Shalini Jain · Wake Forest University

HOLLY BERRY-PRICE · Wake Forest University

Felipe Lorenzo · Wake Forest University

Donald McClain ·

Abstract

Dietary iron and serum ferritin predict the glycemic response to metformin in mouse models and humans with T2D. Protein O-GlcNAcylation has effects paralleling low iron and may play a role in mediating these interactions.

Topics & Keywords

Iron Metabolism and Disorders Trace Elements in Health Hemoglobinopathies and Related Disorders

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Diabetes Metabolic Syndrome and Obesity

Volume Volume 19, pp. 1-19

DOI: 10.2147/dmso.s580024

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