Molecular landscape of prostate cancers with clival metastases

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Authors

Pornlada Likasitwatanakul · University of Minnesota

Steven Blinka · Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa

Jabra Zarka · Mayo Clinic

Georges Gebrael · Huntsman Cancer Institute

Emily S. Weg · Cornell University

Ossian Longoria · Royal Marsden NHS Foundation Trust

Joseph A Moore

Abstract

Prostate cancers giving rise to clival metastases exhibit a distinct molecular profile enriched for DNA damage-repair and RAF kinase alterations, suggesting unique metastatic biology and potential therapeutic vulnerabilities.

Topics & Keywords

Prostate Cancer Treatment and Research Melanoma and MAPK Pathways Prostate Cancer Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Oncologist

Volume 31, Issue 4

DOI: 10.1093/oncolo/oyag074

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