Genomic Therapy Matching in Rare and Refractory Cancers

20260 citationsJournal Articlehybrid Open Access

Authors

Frank P. Lin · The University of Sydney

Subotheni Thavaneswaran · The University of Sydney

John P. Grady · Garvan Institute of Medical Research

Christine E. Napier · Garvan Institute of Medical Research

Maya Kansara · Garvan Institute of Medical Research

Lucille Sebastian · The University of Sydney

Damien Kee

Abstract

In this cohort study of patients with advanced solid tumors, matching therapies to genomic biomarkers was associated with improved survival only when supported by prospective clinical trial evidence. These findings support using an evidence-based framework to prioritize genomically guided therapies.

Topics & Keywords

Cancer Genomics and Diagnostics Lung Cancer Treatments and Mutations Colorectal Cancer Treatments and Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA Oncology

DOI: 10.1001/jamaoncol.2026.0127

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