Direct Oral Anticoagulant Protein Targets and Risk of Cerebral Venous Thrombosis

20260 citationsJournal Article

Authors

Iyas Daghlas · University of California, San Francisco

MARTA PEREZ-ALCANTARA · Sequenom (United Kingdom)

Abstract

We found strong genetic evidence linking FXI to CVT pathogenesis and suggestive genetic evidence for FXa and thrombin. Inhibition of these proteins with DOACs may represent an effective therapeutic strategy for CVT.

Topics & Keywords

Cerebral Venous Sinus Thrombosis Blood Coagulation and Thrombosis Mechanisms Venous Thromboembolism Diagnosis and Management

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurology

Volume 106, Issue 7, pp. e214759-e214759

DOI: 10.1212/wnl.0000000000214759

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