Individual-level metabolic connectivity captures cortical morphology and their coupling strengthens with age

20260 citationsJournal Articlegreen Open Access

Authors

Massimiliano Facca · University of Padua

Claudia Tarricone · University of Padua

Anna Lisa Ridolfo · University of Padua

M. Corbetta · University of Padua

Andrei G. Vlassenko · Mallinckrodt (United States)

Manu S. Goyal · Mallinckrodt (United States)

Alessandra Bertoldo ·

Abstract

Individual-level MC captures the morphometric organisation of the brain. The age-related increase in morphology-metabolism coupling indicates that metabolic coordination becomes progressively more aligned with cortical architecture, consistent with reduced neuroenergetic flexibility in the ageing brain.

Topics & Keywords

Functional Brain Connectivity Studies Advanced MRI Techniques and Applications Dementia and Cognitive Impairment Research

Publication Details

Published in: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.64898/2026.03.03.709267

Field-Weighted Citation Impact: 0.00

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Individual-level metabolic connectivity captures cortical morphology and their coupling strengthens with age

Authors

Abstract

Topics & Keywords

Publication Details