HER2/neu and Ki-67 as prognostic biomarkers in urothelial carcinoma

The prognostic significance of Her2/neu and Ki-67 expression remains insufficiently defined in urothelial carcinoma even though it constitutes a major proportion of malignancies in the male population of the United States and India. Therefore, it is of interest to evaluate Immunohistochemical (IHC) expression of HER2/neu and Ki-67 to correlate with clinicopathological parameters in thirty histologically confirmed cases of urothelial carcinoma in an Indian cohort. We show that the overexpression of HER2/neu and Ki-67 correlates positively with higher tumor grade, advanced stage and may serve as reliable prognostic biomarkers thus guiding therapeutic decision making in management of urothelial carcinoma.