Functional properties of CD+CD25+FoxP3+ T-lymphocytes and their importance for graft-versus-host disease in patients after allogeneic hematopoietic stem cell transplantation

CD4 + CD25 + FoxP3 + regulatory cells (Tregs) are a special lineage of cells central in the maintenance of immune homeostasis. In this review, we have analyzed the available data on CD4 + CD25 + FoxP3 + Tregs. We have summarized the basic information about the various subpopulations of Tregs, the mechanisms of their differentiation, their immunosuppressive properties and the possibility of clinical use in graft-versus-host disease. Now a significant knowledge base has been accumulated about Tregs and clinical trials of their use in patients with graft-versus-host disease have begun.