Childhood Maltreatment and Deviations from Normative Brain Structure: A Mega-Analysis of 3,711 Individuals from the ENIGMA MDD and ENIGMA PTSD Working Groups

20260 citationsJournal Articlehybrid Open Access

Authors

Haley R Wang · University of California, Los Angeles

Zhen-Qi Liu · Montreal Neurological Institute and Hospital

Elena Pozzi · Orygen Youth Health

Ahmed Hussain · Duke University

Priyanka Sigar · University of California, Los Angeles

Chadi G. Abdallah · Baylor College of Medicine

Nina Alexander

Abstract

Our findings of age- and sex-specific instantiations of CM on brain morphometry highlight the importance of developmental context in understanding how adverse experiences shape neurobiological vulnerability to MDD and PTSD.

Topics & Keywords

Child Abuse and Trauma Posttraumatic Stress Disorder Research Child Abuse and Related Trauma

UN Sustainable Development Goals

Reduced inequalities

Publication Details

Published in: Biological Psychiatry

DOI: 10.1016/j.biopsych.2026.02.016

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