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Sami Ahmad Khan’s Aliens in Delhi exhibits diverse issues in a speculative world. The unique intermixing of narratives within the novel aligns with Stacy Alaimo’s concept of trans-corporeality, which emphasizes that the “trans-corporeal subject is generated through and entangled with biological, technological, economic, social, political and other systems, processes and events, at vastly different scales.” By applying Alaimo’s idea, this paper aims to define and develop the term “programmed corporeality” within and beyond its algorithmic connotation. An analysis of the novel reveals the horrific intrusion of “aliens” onto the Earth’s diverse ecologies, putting the human corporeal self at risk, as it is transformed via a mutation of the human genome caused by aliens through cellphone radiation. The novel questions the idea of human exceptionalism as aliens attempt to reclaim the Earth as their long-lost ancestral home, while humans resist using their technological knowledge, leading to a state of war. Bringing posthumanism into dialogue with horror studies, programmed corporeality helps us rethink the implications of discourse in the context of self-organizing phenomena of material entanglement. This article also connects Francesca Ferrando’s post-dualism—“the final deconstruction of the human”—to explain how the concept of programmed corporeality can critique many pressing issues within and beyond the ecological crisis: speculative dimension, genetic engineering, speciesism, interpellation, neo-colonialism, the spatial differences of national borders triggered by geopolitics, and the deconstruction of different binary relations.