P169: 90-month efficacy outcomes with cipaglucosidase alfa plus miglustat in adults with Pompe disease in ATB200-02: An open-label phase I/II study

homocysteine levels or vitamin B12 levels in All of Us (data not available for UK Biobank).Prior associations between MTHFR thermolabile variant heteroor homozygosity and other phenotypes such as thrombosis, stroke, cardiovascular disease, cancer, or congenital malformations of the nervous system were not replicated in this study.Conclusion: Our data showed no significant corroboration of previously linked common conditions including thrombosis, stroke, cardiovascular disease, cancer, or congenital malformations of the nervous system to MTHFR c.665C>T genotypes in these large datasets.These findings strongly support recommendations to not test individuals for MTHFR c.665C>T.