Impact of Chemotherapy on Sperm Functional Characteristics in Patients With Testicular Germ Cell Tumours

20260 citationsJournal Articlehybrid Open Access

Authors

Ondrej Sanovec · Charles University

Ondřej Šimoník · Czech Academy of Sciences, Institute of Biotechnology

Zuzana Kratka · Gennet

Lukáš Děd · Czech Academy of Sciences, Institute of Biotechnology

Jana Vondráková · Czech Academy of Sciences, Institute of Biotechnology

Maryam Qasemi · Czech Academy of Sciences, Institute of Biotechnology

Barbora Bryndova

Abstract

Sperm quality in TGCT patients showed marked variability. Non-seminoma diagnosis appeared less detrimental than seminoma, yet BEP chemotherapy severely impaired sperm parameters, especially in non-seminoma cases. These results highlight the importance of individualized post-chemotherapy monitoring using standard semen analysis, cytometry-based qualitative assessments, and epigenetic profiling of histone modifications to optimize fertility preservation and guide optimal treatment strategies by andrologists.

Topics & Keywords

Testicular diseases and treatments Sperm and Testicular Function Ovarian cancer diagnosis and treatment

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Andrology

DOI: 10.1111/andr.70203

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