Pain Inhibitory Mechanisms Are Unchanged but Facilitatory Mechanisms Are Decreased in Aerobically Fit Individuals Compared to Controls: A Controlled Exploratory Study

This study demonstrates that regular aerobic exercise has a positive impact on endogenous pain modulation by reducing temporal summation, a key facilitatory pain mechanism, in healthy individuals. This contribution advances our understanding of non-pharmacological pain management and may lead to personalised exercise-based strategies for pain relief.