BRISC Deficiency Drives Heart Failure by Regulating β-Catenin K63 Ubiquitination

20260 citationsJournal Article

Authors

Lu Liu · Food & Nutrition

Guang-Ming Ren · Beijing Proteome Research Center

Chen Chen · Beijing Proteome Research Center

Guoyou Liu · Capital Medical University

Wenhui Niu · Food & Nutrition

Xiao-Ming Yang · Beijing Proteome Research Center

Mengdi Wang ·

Abstract

BRISC acts as a critical K63-specific deubiquitinase that preserves cardiac homeostasis by restraining β-catenin overactivation. Targeting the BRISC-β-catenin axis may represent a novel therapeutic strategy for hypertensive heart failure.

Topics & Keywords

Ubiquitin and proteasome pathways Wnt/β-catenin signaling in development and cancer Cancer-related Molecular Pathways

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Hypertension

DOI: 10.1161/hypertensionaha.125.25727

Field-Weighted Citation Impact: 0.00