Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review of Cases Secondary to Topical Medications

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are typically triggered by systemic medications but can also result from topical agents. In this systematic review of SJS/TEN cases caused by topical agents, the drug culprits, disease characteristics, and outcomes were comparable to systemic cases. Our findings highlight that topical formulations, though generally considered safer, can induce SJS and TEN, underscoring the need for clinician awareness, early recognition and accurate reporting.