Different Pattern of Treatment Failure After Chemoradiation Between p16+ and p16− Patients Affected by Oropharyngeal Carcinoma

20260 citationsJournal Articlehybrid Open Access

Authors

R Gili · Ospedale Policlinico San Martino

P. Bossi · Humanitas University

Luca Lalli · National Cancer Institute

L. Licitra · Fondazione IRCCS Istituto Nazionale dei Tumori

Marta Maddalo · University of Brescia

Almalina Bacigalupo · Ospedale Policlinico San Martino

Liliana Belgioia

Abstract

Recurrence patterns in OPC differ by HPV status and smoking history. HPV-positive heavy smokers represent a distinct high-risk subgroup characterized by increased distant metastasis and inferior survival, warranting refined stratification beyond p16 status alone.

Topics & Keywords

Head and Neck Cancer Studies Cancer-related Molecular Pathways Esophageal Cancer Research and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Head & Neck

DOI: 10.1002/hed.70222

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