A novel angiotensin(1-7) agonist, PNA5, reduces ischemic reperfusion injury and cardiac dysfunction

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Authors

Christina Hoyer-Kimura · University of Arizona

Meredith Hay · University of Arizona

Methawasin Methajit · University of Arizona

Polt Rl · University of Arizona

Victoria Salcedo · University of Arizona

Joshua P. Fricks · University of Arizona

Arian Piepho ·

Abstract

These data suggest that PNA5 treatments improve heart outcomes post-IR and could potentially be a therapeutic for IR injury; measures of GLS and dyssynchrony may provide more relevant insight into the protective effects of PNA5.

Topics & Keywords

Cardiac Ischemia and Reperfusion Renin-Angiotensin System Studies Acute Myocardial Infarction Research

Publication Details

Published in: Frontiers in Cardiovascular Medicine

Volume 13, pp. 1769276-1769276

DOI: 10.3389/fcvm.2026.1769276

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A novel angiotensin(1-7) agonist, PNA5, reduces ischemic reperfusion injury and cardiac dysfunction

Authors

Abstract

Topics & Keywords

Publication Details