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A statistically significant association was found between contact allergy to epoxy resin and fragrance mix I (FM I) in Danish wind turbine workers [1]. Surprisingly, the same significant association was found between epoxy resin and FM I in consecutively tested dermatitis patients at the Department of Occupational and Environmental Dermatology in Malmö Sweden [1]. This association has also been reported from Denmark [2] but was not detected in the USA and within the IVDK [3, 4]. The primary aim of this study was to see whether there was any association between contact allergy to epoxy resin and FM I as well as other markers of fragrance allergy in the general population [5-7]. In all, 3012 adult volunteers from the general population were patch tested with the True test methodology including epoxy resin, Myroxolon pereirae, and colophony as described previously [5]. Small Finn chambers were used to test FM I with a high content of chloratranol/atranol [8], as well as the constituents of FM I and FM II [6, 7]; 20 mg of the petrolatum preparations were applied onto the Finn chambers (40 mg/cm2) [9]. The occlusion time on the back was 48 h and the tests were read on day 3 according to the classification of ICDRG [10]. Fisher's exact test, two-sided, was used to investigate any association between epoxy resin and the various markers for fragrance allergy. The results are shown in Table 1. A statistically significant association was seen between contact allergy to epoxy resin and FM I. No other associations were found between epoxy resin and the other tested preparations [6, 7] in True test panels 1–3 and sesquiterpene lactone mix. Indication of association was seen for FM II with a p value at 0.10 as well as for cinnamic alcohol and hydroxyisohexyl 3-cyclohexene carboxaldehyde, constituents of FM I and FM II, with p values at 0.086 and 0.063, respectively. Besides previous demonstration in an occupational setting [1] and in dermatitis patients [1, 2], a statistically significant association between contact allergy to epoxy resin and FM I is also interestingly present in a sample of the European general population [5-8]. Presently, we do not have any explanations on which chemical and/or biological mechanisms are involved in this association. It is also hard to draw any firm conclusions on which chemical structures might be involved based on the indicated association between epoxy resin on the one hand and the cyclic fragrance substances cinnamic alcohol and hydroxyisohexyl 3-cyclohexene carboxaldehyde on the other (Table 1). Investigation of the association between contact allergy to epoxy resin and contact allergy to fragrance mixes with their ingredients needs more individuals with contact allergy to the fragrance mixes than in the present study. Such an investigation could be performed in consecutively tested dermatitis patients. Unlike the present study where there was only one test reading on Day 3 to keep the number of visits at the clinics as low as possible to assure that the volunteers completed the testing, a study in consecutive dermatitis patients should include a test reading also after 1 week. Magnus Bruze: conceptualization, investigation, writing – original draft, methodology, writing – review and editing, project administration. Peter Elsner: investigation, writing – review and editing, data curation. Margarida Goncalo: investigation, writing – review and editing, data curation. Luigi Naldi: investigation, writing – review and editing, data curation. Marie-Louise A. Schuttelaar: investigation, writing – review and editing, data curation. Åke Svensson: investigation, writing – review and editing, data curation. Simone Cazzaniga: investigation, writing – review and editing, data curation. Robert Ofenloch: writing – review and editing, investigation, data curation, methodology. This work was supported by Research Institute for Fragrance Materials Inc. The authors declare no conflicts of interest. The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.