Nintedanib Attenuates Profibrotic Gene Expression in a 3D Organotypic Culture Model of Systemic Sclerosis Skin Fibrosis

Systemic sclerosis (SSc) is a chronic multi-organ disease of unknown etiology characterized by autoimmunity, inflammation, and intractable tissue fibrosis. Due to the absence of validated biomarkers or effective disease-modifying therapies, SSc represents a significant unmet medical need. The early inflammatory stage of SSc is followed by the accumulation of collagen-rich scar tissue that disrupts the architecture and leads to dysfunction and eventual failure of the skin, lungs, and other organs(Pope et al.