Six-Week Protocol for Two-Stage Exchange Arthroplasty in a High-Risk Population

A shortened multidisciplinary 6-week protocol for 2-stage exchange revisions is a viable, reliable, and effective strategy for managing PJI. Despite a high-risk population with osteomyelitis and mega-prostheses, outcomes were similar or better than traditional approaches. This shortened protocol demonstrated high eradication rates while potentially reducing resource utilization, costs, and patient's burden.