AI-augmented communication improves HIV PrEP initiation and persistence in populations disproportionately impacted by HIV

This retrospective cohort study evaluated an AI-powered chatbot used for PrEP support across AIDS Healthcare Foundation clinics in the United States. Among 155,217 eligible adults, individuals who engaged with the chatbot had higher rates of PrEP initiation, follow-up attendance, and appointment adherence than non-users. Engagement was greatest among younger and racial or ethnic minority patients. Findings suggest that AI-supported communication may enhance aspects of PrEP care delivery.