Evaluation of selected parameters of a soothing emollient cream for atopic and sensitive skin

Introduction: Atopic dermatitis is a chronic skin disease characterized by impaired barrier function and itching, often accompanied by inflammation. Emollients play a key role in therapy. Aim: This study aimed to evaluate an emollient cream specifically designed for individuals with atopic, sensitive, and dry skin. Materials and methods: The safety and efficacy of an oilin-water emulsion, which is a class I medical device, were evaluated using in vitro and in vivo studies. In vitro tests involved the determination of cytotoxicity and irritation potential in cell models and reconstructed human epidermis, while in vivo studies included patch testing, clinical evaluation of efficacy, and instrumental measurements of skin parameters. In addition, an observational use study was conducted in people with atopic dermatitis to evaluate the effects of the product and user satisfaction. Results: An in vitro evaluation, including cytotoxicity and irritation potential tests in an epidermal model, confirmed that the tested preparation had no irritating effect. In vivo studies showed improved skin hydration, support for the lipid barrier, and a smoothing effect, with the level of hydration persisting for at least five hours after application. An observational study revealed that over 70% of participants reported improved hydration and experienced relief from skin tightness. The reduction in itching was less pronounced. The product was well tolerated, and patch tests showed no allergic reactions. Conclusions: Emollients are an essential and effective component in the treatment of skin with a disturbed hydrolipid barrier. However, the study’s results emphasise the need for a variety of preparations tailored to individual preferences and the range of symptoms.