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ABSTRACT This is a short interview with Professor Timothy J. Eberlein, conducted by Professor Ken Shirabe, President of the Japanese Society of Gastroenterological Surgery, explores the vision, strategies, and leadership behind developing the Siteman Cancer Center into a world‐class institution. Professor Eberlein emphasizes two central goals: becoming experts in every type of cancer and ensuring that every patient feels uniquely cared for. He highlights the importance of large‐scale clinical programs in sustaining a virtuous cycle of academic medicine, where clinical revenue supports research and education, and innovations attract both patients and trainees. A distinctive element of his philosophy is individualized training, offering flexibility for surgical residents to focus on areas such as oncology, minimally invasive surgery, or education. He underscores the critical role of mentorship, collaboration, and laboratory organization in nurturing surgeon‐scientists. Balancing surgery and research is described as a delicate challenge, but one that can be overcome with proper mentorship and collaboration. Leadership is about leading by example, solving problems for others, and respecting every member of the healthcare team. He stresses that surgery is the ultimate team sport, with outcomes dependent on the collective contributions of diverse professionals. Finally, his message to the next generation of surgeons and oncologists in Japan is to maintain their passion, embrace innovation, and realize that the future holds opportunities, such as genetic therapies, vaccines, and immune therapies that will revolutionize cancer treatment when combined with surgical expertise.