Two Successful Pregnancies in Women With Swyer Syndrome Using Oocyte Donation: Case Report

Women with Swyer syndrome must be informed that pregnancy is possible through oocyte donation, although it carries medical risks and requires careful preparation, including hormone treatment and gonadectomy. We present two cases of Swyer syndrome in which live births were achieved through oocyte donation and reviewed prior reports identifying a high rate of preeclampsia and Caesarean section as significant outcomes. Oocyte donation carries medical risks, such as preeclampsia, raises social issues which are unsolved yet, especially in Japan, where oocyte donation is usually anonymous. Nevertheless, strengthened collaboration between reproductive medicine and perinatal care is necessary, as is the development of social support systems to enable women with Swyer syndrome to achieve pregnancy more safely.