PAR2 deletion in the osteoblast lineage affords long-term cartilage protection in experimental osteoarthritis

20260 citationsJournal Articlehybrid Open Access

Authors

C Huesa · University of Glasgow

S McGrath · University of Glasgow

L Dunning · University of the West of Scotland

M.L Vieri · University of Glasgow

K McCulloch · University of the West of Scotland

K.A. McIntosh · University of Strathclyde

T. Brown ·

Abstract

This suggests that PAR2 expression in the bone compartment promotes joint deterioration in later stages of OA, highlighting the importance of bone turnover as a mechanism which influences joint degradation, and the complexity of PAR2-mediated effects, with age-dependent and cell-specific roles.

Topics & Keywords

Osteoarthritis Treatment and Mechanisms Fatty Acid Research and Health Pharmacological Effects of Medicinal Plants

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Osteoarthritis and Cartilage

DOI: 10.1016/j.joca.2026.03.004

Field-Weighted Citation Impact: 0.00