Endoplasmic reticulum–mitochondria contact sites are signalling hubs connecting nutrient sensing and GLP-1 secretion in L cells of the mouse gut: from physiology to obesity and type 2 diabetes

These results point to a new role for ER-mitochondria calcium coupling in glucose-induced GLP-1 secretion in L cells of the gut, which is impaired in obesity and type 2 diabetes, providing a novel target for the modulation of GLP-1 secretion. Therefore, these data reinforce the potential targeting of MAMs to improve glycaemic outcomes in metabolic diseases.