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Introduction: Bodybuilding is fundamentally influenced by biomechanical efficiency, which plays a crucial role in optimizing muscular development and minimizing the risk of injury. Despite its widespread significance, the systematic integration of biomechanical principles in bodybuilding practice remains insufficiently explored, especially within emerging fitness communities. Objective: The primary aim of this systematic review is to synthesize current scientific evidence regarding the biomechanical principles that underpin effective bodybuilding techniques. The review seeks to identify key mechanical factors that influence performance outcomes and to propose practical recommendations for enhancing training efficacy and athlete safety. Methodology: A comprehensive analysis of 23 peer-reviewed studies was conducted, focusing on the relationship between biomechanical variables such as joint angles, body alignment, and load application and their effects on muscle recruitment and strength enhancement. The studies were selected based on relevance, methodological quality, and contribution to applied bodybuilding biomechanics. Results: The findings indicate that precise manipulation of joint positioning, optimized load distribution, and correct body posture significantly improve muscle activation and strength development. These elements, when systematically applied, contribute to greater training efficiency and reduced injury incidence. Discussion: The outcomes of this review corroborate existing literature in sports science, while offering bodybuilding-specific insights that address a notable research gap. The contextual relevance to Albania further underscores the need for biomechanical education in evolving fitness sectors.Conclusions: Incorporating biomechanical principles into bodybuilding training can substantially improve performance, safety, and long-term health outcomes. Future research should pursue longitudinal and intervention-based studies to further validate these findings and inform practice.