Pattern of Somatic Mutations in the PIK3CA Oncogene and Their Role as a Potential Prognostic Biomarker in Breast Cancer Patients in Sri Lanka: A Pilot Study

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Authors

Tharini Ruwinya Cabraal · University of Colombo

Iranthi Kumarasinghe · General Sir John Kotelawala Defence University

Ranga Perera · General Sir John Kotelawala Defence University

Jayantha Balawardana · General Sir John Kotelawala Defence University

Sameera Viswakula · University of Colombo

Nandika Perera · Genetech (Sri Lanka)

Gayani Galhena

Abstract

Despite being a pilot study, the findings indicate that PIK3CA mutations are associated with adverse prognostic outcomes in Sri Lankan breast cancer patients. These results demonstrate the potential utility of PIK3CA testing and PI3K-targeted therapy in clinical management in Sri Lankan, pending validation in larger cohorts.

Topics & Keywords

PI3K/AKT/mTOR signaling in cancer BRCA gene mutations in cancer Biological Research and Disease Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Asian Pacific Journal of Cancer Prevention

Volume 27, Issue 3, pp. 897-910

DOI: 10.31557/apjcp.2026.27.3.897

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