Benchmark dose modelling in a UK chemical risk assessment framework

The Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) evaluated the use of benchmark dose (BMD) modelling within the UK’s chemical risk assessment framework. The report outlines the theoretical basis, practical application and regulatory context of BMD modelling, comparing it with traditional NOAEL and LOAEL approaches. It reviews international guidance, assesses available modelling tools and includes a PFAS case study illustrating how BMD modelling supports the development of health‑based guidance values. The COT highlighted the scientific strengths of BMD modelling while noting challenges around transparency, data suitability and practical implementation for regulatory use.