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In 2025, the Author published an article regarding the potential harmful effects of mirrors, in which several folk superstitions were analyzed from the perspective of real physics. Currently, there is a lack of rigorous scientific data to completely refute these superstitions, partly because the study of such phenomena is not typically con sidered a significant research problem. Consequently, the article sparked intense debate regarding its scientific merit, with some critics suggesting it was "reduced to the level of folklore." However, the article does not focus on "folklore," but rather on the "potential harm of mirrors" and the necessity for a definitive scientific conclusion – either positive or negative – based on rigorous empirical research. The justification for the potential harm of mirrors is framed not as a final assertion, but as a hypothesis requiring experimental verification. The basis for the conclusion regarding the possible harm of mirrors is the proposition that they reflect incident photons as antiphotons with the opposite rotation of electromagnetic waves (spin). It is well-established that clockwise and counter-clockwise rotations of electromagnetic fields exert different effects on organic and inorganic molecules, as well as on biological cells and organisms as a whole. Therefore, the primary objective of this work is to provide a scholarly rationale for a series of experiments, suitable for doctoral-level research, that can scientifically prove or disprove the harmful influence of mirrors on the biological domain of the material world. Methodology: Based on the application of general principles of scientific inquiry and the fundamental laws of nature and physics, which do not contradict the existing characteristics of the material world. Results: include a more robust physical justification for the processes, phenomena, and effects leading to the conversion of photons into antiphotons during mirror reflection, as well as a rebuttal of the AI-generated criti cism of previous works. An analysis of this criticism is provided, its shortcomings are identified and corrected, and specific tasks for experimental procedures are formulated. Conclusions: On a realistic physical basis, it is demonstrated that photons of visible light, when reflected by mirrors, are inverted into antiphotons with reversed rotation of their electromagnetic waves and fields, which may have a deleterious effect on biological objects. A range of potential biophysical experiments has been sub stantiated to confirm or refute the harmful influence of mirrors.