Divergent Immunological and Neurotrophic Responses to CD20 Depletion in Relapsing and Progressive Multiple Sclerosis

20260 citationsJournal Articlegold Open Access

Authors

Gudrun Körner · Medizinische Hochschule Hannover

Thiemo Malte Möllenkamp · Medizinische Hochschule Hannover

Konstantin F. Jendretzky · Medizinische Hochschule Hannover

Julian Reza Kretschmer · Medizinische Hochschule Hannover

Anna Christina Saparilla Pietschmann · Medizinische Hochschule Hannover

Janna Margaretha Siemer · Medizinische Hochschule Hannover

Jarle von Hörsten

Abstract

Our findings support divergent immunological mechanisms in RMS and PPMS, with a stronger cytokine-driven pathology and more pronounced immunomodulatory effects of ocrelizumab on the cytokine profile in patients with RMS.

Topics & Keywords

Multiple Sclerosis Research Studies Immunotherapy and Immune Responses vaccines and immunoinformatics approaches

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurology and Therapy

DOI: 10.1007/s40120-026-00908-0

Field-Weighted Citation Impact: 0.00