Enhancing care for women with premature ovarian insufficiency: The need for multidisciplinary management and research

Premature ovarian insufficiency (POI) is a complex condition associated with significant reproductive, metabolic, skeletal, and psychosocial implications. Although international and national guidelines outline diagnostic criteria and management pathways, substantial gaps remain in transition of this knowledge into patient care models. Most Indian studies are limited to isolated case reports focusing mainly on genetic or autoimmune causes, providing only a partial understanding of the broader clinical and long-term needs of women with POI. This review highlights the need for a structured, multidisciplinary care model.To address this gap, a multidisciplinary POI clinic has been established at the infertility clinic of the ICMR-National Institute for Research in Reproductive and Child Health, Mumbai. Staffed by gynecologists, reproductive endocrinologists, immunologists, geneticists, IVF specialists, social workers, and basic scientists, the clinic offers an integrated platform for comprehensive evaluation and management. The model is built on three pillars: thorough clinical and laboratory assessment with personalized counseling; development of a longitudinal cohort with annual follow-ups to track metabolic, autoimmune, and clinical changes; and collaborative research to generate population-specific evidence.This initiative marks an important step forward for POI care in India.