Importin-8 silencing reduces Ataxin-3 aggregation and alleviates Machado-Joseph disease/Spinocerebellar ataxia type 3

Dataset for: Importin-8 silencing reduces Ataxin-3 aggregation and alleviates Machado-Joseph disease/Spinocerebellar ataxia type 3 This repository contains the supplementary data and unprocessed raw datasets supporting the study of nucleocytoplasmic transport dysregulation in Machado–Joseph disease (MJD). The research identifies Importin-8 (Ipo8) as a key modulator of Ataxin-3 (Atxn-3) aggregation and neuronal dysfunction.