Targeted management of adenomyosis: frozen embryo transfer outcomes with GnRH-agonist and letrozole therapy: a case series

Adenomyosis-related infertility remains a challenge. This case series supports the potential efficacy of hormonal suppression by combining GnRH agonists, aromatase inhibitors, and diagnostic hysteroscopy with saline irrigation prior to the endometrial preparation for euploid frozen embryo transfer in patients with adenomyosis. This protocol offers a promising alternative for cases unresponsive to standard treatments, although further research is warranted to refine guidelines on treatment duration and dosage.