Total alkaloids of Leonurus alleviate allergic asthma and inflammation responses by inhibiting hypoxia-induced factor-1⍺-mediated mast cell activation

20260 citationsJournal Articlegold Open Access

Authors

Yannan Zheng · Shanghai University of Traditional Chinese Medicine

Mingyue Lv · Shanghai University of Traditional Chinese Medicine

Zhichao Xi · Shanghai University of Traditional Chinese Medicine

Jijia Sun · Shanghai University of Traditional Chinese Medicine

Mengfan Liu · Shanghai University of Traditional Chinese Medicine

Trinh T. Nguyen · Shanghai University of Traditional Chinese Medicine

Abstract

TAL alleviates allergic asthma by suppressing HIF-1α-mediated mast cell activation and associated inflammation responses, supporting its potential application in inflammatory airway diseases.

Topics & Keywords

Mast cells and histamine Quinazolinone synthesis and applications Asthma and respiratory diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Frontiers in Pharmacology

Volume 17, pp. 1783196-1783196

DOI: 10.3389/fphar.2026.1783196

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