Truncating Variants in <i>TTN</i> are Associated With Primary Atrial Myopathy

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Authors

Daniel de Castro · Centro de Investigación en Red en Enfermedades Cardiovasculares

Diane Fatkin · St. Vincent's Birmingham

Enrique Rodriguez‐Rubio · Instituto de Investigación Sanitaria de Santiago

F. Haddad · Stanford University

Fernando Hernández‐Terciado · Clinica Universidad de Navarra

Anisha Purohit · Brigham and Women's Hospital

Sharareh Bagherzadeh

Abstract

LA myopathy, detected by strain imaging, appears early in TTNtv+/DCM- individuals and may represent an early phenotypic marker independent of left ventricular systolic dysfunction. When LVEF declines below 50%, atrial dysfunction worsens in parallel. AF was more frequent in TTNtv carriers, supporting further research on LA strain for AF risk stratification within this population.

Topics & Keywords

Cardiomyopathy and Myosin Studies Cardiovascular Effects of Exercise Cardiac Arrhythmias and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of the American Heart Association

Volume 15, Issue 6, pp. eJAHA2025047740T-eJAHA2025047740T

DOI: 10.1161/jaha.125.047740

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