Schizophrenia endophenotypes: a review of neurophysiological, neuropsychological, and social cognition markers

Current data confirm the utility of neurophysiological and neuropsychological markers as established endophenotypes. While specific social cognition components require further validation, recent investigations demonstrate greater impairments in SCZ on mentalization tasks compared to other psychiatric conditions. The integration of these markers is relevant for stratified psychiatry and treatment personalization. Furthermore, recent findings suggest a transdiagnostic role for certain endophenotypes, indicating shared neural vulnerabilities across the schizoaffective spectrum.