Enhancing Respiratory Support in COPD Patients with Nasal High Flow Using an Asymmetrical Cannula Interface: A Randomized Cross-Over Study

NHF reduced RR by increasing both expiratory and inspiratory times without altering the duty cycle. The lower MV during NHF with AI, accompanied by higher SpO₂, may indicate improved gas exchange efficiency. The use of AI could enhance the respiratory support effects of NHF in patients with advanced COPD.