Distinct proteomic profiles of clinical isolates show diversity of Pseudomonas aeruginosa colistin-resistance

20260 citationsJournal Articlegold Open Access

Authors

Telma de Sousa · University of Trás-os-Montes and Alto Douro

Thierry Sayd · Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Didier Viala · Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Christophe Chambon · Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Manuela Caniça · Instituto Nacional de Investigação Agrária e Veterinária

Miguel J. N. Ramos · National Institute of Health Dr. Ricardo Jorge

Abstract

The findings have direct implications for the choice of alternative therapies and the development of optimized dosing regimen. In summary, the results reinforce the complexity of resistance mechanisms in P. aeruginosa and highlight the importance of personalized therapeutic approaches for the management of infections caused by multidrug-resistant isolates.

Topics & Keywords

Antibiotic Resistance in Bacteria Bacterial biofilms and quorum sensing Infections and bacterial resistance

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Clinical Proteomics

DOI: 10.1186/s12014-026-09592-6

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