Mutant KRAS Heterogeneity Shapes Nuclear Architecture During Pancreatic Cancer Initiation

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Authors

Gareth Pollin · Medical College of Wisconsin

Angela Mathison · Medical College of Wisconsin

Elise Leverence · Medical College of Wisconsin

Thiago M. de Assuncao · Medical College of Wisconsin

Juan Iovanna · Centre National de la Recherche Scientifique

Johnny C. Hong · Mercy St. Vincent Medical Center

Michael T. Zimmermann

Abstract

Together, these findings demonstrate that KRAS mutational context in pancreatic ductal epithelial cells shapes early transcriptional reprogramming that actively remodels nuclear architecture and nuclear sub-compartments. This work establishes nuclear structural remodeling as a structural state of KRAS-driven epigenetic dysregulation during PDAC initiation.

Topics & Keywords

Pancreatic and Hepatic Oncology Research Protein Kinase Regulation and GTPase Signaling Pancreatic function and diabetes

Publication Details

Published in: Epigenomes

Volume 10, Issue 1, pp. 19-19

DOI: 10.3390/epigenomes10010019

Field-Weighted Citation Impact: 0.00

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Mutant KRAS Heterogeneity Shapes Nuclear Architecture During Pancreatic Cancer Initiation

Authors

Abstract

Topics & Keywords

Publication Details