Correlation of global and regional quantitative 99mTc-3,3-diphosphono-1,2 propanodicarboxylicacid single-photon emission computed tomography with echocardiography in patients with suspected transthyretin-related cardiomyopathy

The robust correlation found between TTE-derived parameters and the corresponding [ 99m Tc]Tc-DPD SPECT SUVs supports the link between morphologic alterations and [ 99m Tc]Tc-DPD activity within the myocardium, also potentially highlighting a pathophysiological mechanism involved in the progression of ATTR-CM.