Progastrin, annexin A2, and tumor-associated macrophages in gastric adenocarcinoma

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Authors

Konstantinos Christofidis · National and Kapodistrian University of Athens

Rodanthi Fioretzaki · Laiko General Hospital of Athens

Stylianos Mavropoulos Papoudas

Nikolaos Charalampakis · Metaxa Hospital

Nikolaos Kavantzas · National and Kapodistrian University of Athens

Dimitrios Schizas · Laiko General Hospital of Athens

Stratigoula Sakellariou · National and Kapodistrian University of Athens

Abstract

This study is the first to demonstrate the adverse prognostic impact of ANXA2 overexpression in gastric adenocarcinoma tissues from Caucasian patients. Our results suggest that ANXA2 might have utility as a prognostic biomarker and therapeutic target, if further large-scale studies validate and expand our findings.

Topics & Keywords

S100 Proteins and Annexins Immune cells in cancer Clusterin in disease pathology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Pathology and Translational Medicine

Volume 60, Issue 2, pp. 263-279

DOI: 10.4132/jptm.2025.12.20

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