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Infections in relation to the heart could be localised, as in a mycotic aneurysm, or systemic (as in infective endocarditis with septicemia). Echocardiography remains a mainstay in diagnosing native valve endocarditis. However, it has limitations in prosthetic valve endocarditis. An infected cardiac device is another challenge for direct visualisation of the focus of infection, and computed tomography (CT) and magnetic resonance imaging have limited application other than the detection of structural changes such as an aneurysm. Fluorine 18-fluorodeoxyglucose positron emission tomography-computed tomography is a sensitive tool to detect a focus of infection/inflammation, but its use in detecting myocardial inflammation involves stringent preparations such as prolonged fasting and preadministration of heparin. Gallium-68-fibrinogen activation protein inhibitor is a recently introduced molecule which overcomes this difficulty, as it does not show any uptake in the normal heart. It does not require fasting status or stringent control of blood sugar. It does localise to the site of infarction, and there is limited literature related to its use in infections involving the heart. This report presents six cases with clinical suspicion of infections involving stents, the endocardium, and cardiac implantable electronic devices, where nuclear medicine procedures played a crucial role in influencing the diagnosis.