Comparison of hyaluronic acid, chlorhexidine and persica during SRP

The optimal choice of local drug delivery agents for chronic periodontitis treatment remains uncertain. This study compared 0.8% hyaluronic acid (HA), 0.2% chlorhexidine (CHX) and 10% Salvadora persica (SP) gels versus SRP alone in stage I and II chronic periodontitis patients. 100 patients were randomized into four groups: HA gel, CHX gel, SP gel and SRP alone. Results showed significant clinical improvement with HA showing superior wound healing, CHX having the best antimicrobial effects but higher side effects and SP demonstrating minimal side effects with adequate antimicrobial potential. This study contributes to the understanding of the efficacy and safety of different local drug delivery agents, offering guidance for periodontists in clinical practice.