The Multifaceted Menace of Fusarium as a Plant, Animal, and Human Pathogen

<i>Fusarium</i> is a diverse genus of filamentous fungi that has long been recognized for its importance in plant disease and food security. Beyond its agricultural impact, a growing number of studies now show that <i>Fusarium</i> species can also act as opportunistic pathogens in animals and humans. This review synthesizes current knowledge on <i>Fusarium</i> biology by integrating perspectives from plant pathology, veterinary science, and medical mycology. We examine how shared virulence mechanisms, environmental reservoirs, and genomic plasticity-including accessory chromosomes and horizontal gene transfer-facilitate adaptation across plant, animal, and human hosts. We also consider the role of environmental change in shaping the distribution and pathogenic potential of this genus. By bringing together evidence that is often scattered across disciplines, this review emphasizes the need to move beyond host-specific views and highlights <i>Fusarium</i> as a useful model for understanding fungal adaptability and cross-kingdom pathogenicity within a One Health framework.