Estrogen Metabolism–Related Lifestyle Score and Risk of Postmenopausal Breast, Endometrial, and Ovarian Cancers: Findings from Two Large Prospective Cohort Studies

Elevated estrogen 2-OH has been linked to reduced breast cancer risk. We showed that lifestyle patterns increasing the 2-OH EM/parent E ratio were associated with lower postmenopausal breast and endometrial cancer risk. Our findings suggest that targeted lifestyle modifications may benefit postmenopausal women with a low 2-OH EM/parent E ratio.