Medical ozone for the treatment of certain cervical diseases: A review

The mixture of ozone and oxygen (O3–O2, 5:95) is called "medical ozone." Ozone therapy, which uses an ozone-oxygen mixture, is applied for a wide range of diseases, including certain cervical diseases. It is also used in other branches of medicine, such as the treatment of purulent wounds, inflammatory-degenerative diseases, and circulatory disorders. In cervical diseases, low concentrations of ozone used therapeutically do not cause toxic effects and exhibit immunomodulatory, anti-inflammatory, bactericidal, antiviral, fungicidal, antihypoxic, reparative, and related effects. Ozone therapy has shown efficacy in the treatment of benign cervical diseases, including those associated with HPV, which justifies its further research. For severe dysplasia, ozone therapy may be considered an adjunctive method of rehabilitation, rather than a substitute for surgical treatment.