Cerebral amebiasis due to <i>Acanthamoeba</i> sp. in a patient with complete gp91 <i>phox</i> deficiency

Rare variants in <i>CYBB</i> (encoding gp91 ^<i>phox</i> ) are responsible for chronic granulomatous disease. We report a patient affected by multiple cerebral abscesses caused by <i>Acanthamoeba</i> <i>sp</i>. and complete gp91 ^<i>phox</i> deficiency. The respiratory burst evaluation is recommended in any child with a deep abscess.