P02.11 Impact of systemic polychemotherapy in patients with pancreatic ductal adenocarcinoma on CAR T cell production and function

survival.In vivo imaging demonstrated that TAM/M interact with CAR T-cells, which were reduced following CSF1R inhibition, suggesting TAM/M-mediated impairment of CAR T-cell trafficking.Conclusion Our findings demonstrate that TAM/M contribute significantly to CAR T-cell suppression in lung cancer brain metastases.Targeting CSF1R on TAM/M improved CAR T-cell trafficking, intratumoral persistence and therapeutic efficacy resulting in a survival benefit.These results pave the way for combinatorial strategies incorporating CSF1R inhibition to further enhance CAR T-cell functionality and improve outcomes in the treatment of brain metastases.P02.